Nanopore Papers

Single-molecule analysis of DNA-protein complexes using nanopores. Hornblower B, Coombs A, Whitaker RD, Kolomeisky A, Picone SJ, Meller A, Akeson M. Nature Methods. published online 2007 March 4.

Nanopore sensors for nucleic acid analysis. Nakane JJ, Akeson M, Marziali A. J Phys Condensed Matter. 2003 Aug 20; 15(32):R1365-93.

Highly accurate classification of Watson-Crick basepairs on termini of single DNA molecules. Winters-Hilt S, Vercoutere W, DeGuzman VS, Deamer D, Akeson M, Haussler D. Biophys J. 2003 Feb; 84(2 pt 1):967-76.

Discrimination among individual Watson-Crick base pairs at the termini of single DNA hairpin molecules. Vercoutere WA, Winters-Hilt S, DeGuzman VS, Deamer D, Ridino SE, Rodgers JT, Olsen HE, Marziali A, Akeson M. Nucleic Acids Res. 2003 Feb 15; 31(4):1311-8.

Biosensors for DNA sequence detection. Vercoutere W, Akeson M. Curr Opin Chem Biol. 2002 Dec; 6(6):816-22.

Evaluation of nanopores as candidates for electronic analyte detection. Nakane J, Akeson M, Marziali A. Electrophoresis. 2002 Aug; 23(16):2592-601.

Use of a nanoscale pore to read short segments within single polynucleotide molecules. Akeson M, Deamer DW, Vercoutere W, Braslau R, Olsen H. In: Structure and Dynamics of Confined Polymers, J Kasianowicz, M Kellermayer, D Deamer (eds). Bikal, Hungary, 2002, pp. 187-200.

Mechanism of ionic current blockades during polymer transport through pores of nanometer dimensions. Deamer DW, Olsen H, Akeson MA, Kasianowicz J. In: Structure and Dynamics of Confined Polymers, J Kasianowicz, M Kellermayer, D Deamer (eds). Bikal, Hungary, 2002, pp.165-176.

Rapid discrimination among individual DNA hairpin molecules at single nucleotide resolution using an ion channel. Vercoutere W, Winters-Hilt S, Olsen H, Deamer D, Haussler D, Akeson M. Nat Biotechnol. 2001 Mar; 19(3):248-52.

New DNA sequencing methods. Marziali A, Akeson M. Annu Rev Biomed Eng. 2001; 3:195-223. (Listed among the most cited articles in the Annual Review in Biomedical Engineering Series based on results from 2002-2003.)

Nanopores and nucleic acids: prospects for ultrarapid sequencing. Deamer DW, Akeson M. Trends Biotechnol 2000 Apr; 18(4):147-51.

Water transport by the bacterial channel alpha-hemolysin. Paula S, Akeson M, Deamer D. Biochim BiophysActa. 1999 Apr 14; 1418(1): 117-26.

Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers or as segments within single RNA molecules. Akeson M, Branton D, Kasianowicz JJ, Brandin E, Deamer DW. Biophys J. 1999 Dec; 77(6):3227-33.

Other Research

An aspartate residue at the extracellular boundary of TMII and an arginine residue in TMVII of the gastrin-releasing peptide receptor interact to facilitate heterotrimeric G-protein coupling. Donohue PJ, Sainz E, Akeson M, Kroog GS, Mantey S, Battey JF, Jensen RT, and Northup JK. Biochemistry. 1999; 38(29):9366-72.

Pharmacology and cell biology of the bombesin receptor subtype 4 (BB4-R). Katsuno T, Pradhan TK, Ryan RR, Mantey SA, Hou W, Donohue PJ, Akeson MA, Spindel ER, Battey JF, Coy DH, and Jensen RT. Biochemistry. 1999; 38(22):730720.

Four amino acids are critical for high affinity binding of neuromedin B to the neuromedin B receptor. Sainz E, Akeson M, Mantey SA, Jensen RT, and Battey JF. J Biological Chem. 1998; 273:15927-32.

Loss of bombesin-induced feeding suppression in gastrin- releasing peptide receptor deficient mice. Hampton L, Ladenheim EE, Akeson M, Way JM, Weber HC, Sutliff VE, Jensen RT, Wine LJ, Arnheiter H, Battey JF. Proc Nat Acad Sci (PNAS). 1998; 95:3188-92.

Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. Mantey SA, Weber CH, Sainz E, Akeson M, Ryan RH, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen, RT. J Biological Chem. 1997 Jul 11; 272(41):26062-71.

Identification of four amino acids in the gastrin-releasing peptide receptor that are required for high affinity agonist binding. Akeson M, Sainz E, Mantey SA, Jensen RT, Battey JF. J Biological Chem. 1997 Jul 11; 272(28):17405-9.

Effect of gastrin-releasing peptide receptor number on receptor affinity, coupling, degradation, and modulation. Tsuda T, Kusui T, Hou W, Benya RV, Akeson MA, Kroog GS, Battey JF, Jensen RT. Molec Pharmacol. 1997 May; 51(5):721-32.

The gastrin-releasing peptide receptor is rapidly phosphorylated by a kinase other than protein kinase C after exposure to agonist. Kroog GS, Sainz E, Worland PJ, Akeson MA, Benya RV, Jensen RT, Battey JF. J Biological Chem. 1995 Apr 7; 270(14):8217-24.

Internalization of the gastrin-releasing peptide receptor is mediated by both phospholipase C-dependent and -independent processes. Benya RV, Akeson M, Mrozinski J, Jensen RT, Battey JF. Molec Pharmacol. 1994 Sep; 46(3):495-501.

The role of water in proton conductance across model and biological membranes. Deamer DW, Akeson MA. pp 41-54 in Biomembrane Electrochemistry, ACS Advances in Chemistry Series No. 235, 1994, M. Blank and I. Vodyanoy, Editors.

Stabilization of intercellular contacts in MDCK cells during Ca2+ deprivation. Selective effects of monocarboxylic acids on desmosomes. Bogner P, Skehan P, Kenney S, Sainz E, Akeson MA, Friedman SJ. J Cell Sci. 1992 Oct; 103(Pt 2):463-73.

Evidence that plasma membrane electrical potential is required for vesicular stomatitis virus infection of MDCK cells: a study using fluorescence measurements through polycarbonate supports. Akeson M, Scharff J, Sharp CM, Neville DM Jr. J Membrane Biology. 1992 Jan; 125(1):81-91.

Evidence that sensitivity to steroid anesthetics appears late in evolution. Oliver AE, Deamer DW, Akeson M. Brain Res. 1991 Aug 23; 557(1-2):298-302.

Proton conductance by the gramicidin water wire. Model for proton conductance in the F1F0 ATPases? Akeson M, Deamer DW. Biophysical J. 1991 Jul; 60(1):101-9.

Anesthetics and membranes: A critical review. Akeson M, Deamer DW. Advances in Membrane Fluidity. 1991; 4:71-89.

Sensitivity to anesthesia by pregnanolone appears late in evolution. Oliver AE, Deamer DW, Akeson M. Annals New York Acad Sci. 1991; 625:561-5.

Uptake of aluminum into root cytoplasm: Predicted rates for important solution complexes. Akeson MA, Munns DN. J Plant Nutrition. 1991; 13:467-84.

Steady-state catecholamine distribution in chromaffin granule preparations: A test of the pump-leak hypothesis of general anesthesia. Akeson MA, Deamer DW. Biochemistry. 1989; 28: 5120-7.

Adsorption of Al3+ to phosphatidylcholine vesicles. Akeson MA, Munns DN, Burau RG. Biochimica Biophys Acta. 1989 Nov 17; 986(1):33-40.

Lipid bilayer permeation by neutral aluminum citrate and by three a-hydroxy carboxylic acids. Akeson MA, Munns DN. Biochim Biophys Acta. 1989 Sep 4; 984(2):200-6.

Fluoride matrix modifiers for the determination of Al by graphite furnace atomic absorption spectroscopy. Nater EA, Bura RG, Akeson MA. Analytica Chimica Acta. 1989; 225:233-9.

Copper deficiency in tule elk at Point Reyes, California. Journal of Range Management. Gogan PJ, Jessup DA, Akeson M. 1989; 42: 233-8.


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Mark Akeson

Co-Director, UCSC Biophysics Laboratory

Professor, Biomolecular Engineering