Inferring temporal signaling pathways and regulatory networks, and classifying cell types from high-throughput data

Siddhartha Jain
Speaker Name: 
Siddhartha Jain
Speaker Organization: 
Computer Science Department, Carnegie Mellon University
Start Time: 
Tuesday, May 16, 2017 - 11:00
End Time: 
Thursday, May 11, 2017 - 12:31
Location: 
599 Engineering 2

Abstract

Cells need to be able to sustain themselves, divide, and adapt to new stimuli. Proteins are key agents in regulating these processes. In all cases, the cell behavior is regulated by signaling pathways and proteins, called transcription factors, which regulate what and how much of a protein should be manufactured. Anytime a new stimulus arises, it can activate multiple signaling pathways by interacting with proteins on the cell surface (if it is an external stimulus) or proteins within the cell (if it is a virus for example). Disruption in signaling pathways can lead to a myriad of diseases, including cancer.

 

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